[HTML][HTML] Epitope analysis of the malaria surface antigen pfs48/45 identifies a subdomain that elicits transmission blocking antibodies
N Outchkourov, A Vermunt, J Jansen, A Kaan… - Journal of Biological …, 2007 - ASBMB
Pfs48/45, a member of a Plasmodium-specific protein family, displays conformation-
dependent epitopes and is an important target for malaria transmission-blocking (TB)
immunity. To design a recombinant Pfs48/45-based TB vaccine, we analyzed the
conformational TB epitopes of Pfs48/45. The Pfs48/45 protein was found to consist of a C-
terminal six-cysteine module recognized by anti-epitope I antibodies, a middle four-cysteine
module recognized by anti-epitopes IIb and III, and an N-terminal module recognized by anti …
dependent epitopes and is an important target for malaria transmission-blocking (TB)
immunity. To design a recombinant Pfs48/45-based TB vaccine, we analyzed the
conformational TB epitopes of Pfs48/45. The Pfs48/45 protein was found to consist of a C-
terminal six-cysteine module recognized by anti-epitope I antibodies, a middle four-cysteine
module recognized by anti-epitopes IIb and III, and an N-terminal module recognized by anti …