Protective and pathogenic roles for mast cells during viral infections
APS Rathore, AL St John - Current opinion in immunology, 2020 - Elsevier
Current opinion in immunology, 2020•Elsevier
Highlights•At the host-environment interfaces such as skin or mucosae mast cells act as
immune sentinels for variety of pathogens including viruses.•Mast cells initiate cellular
immune responses at the infection site by recruitment of various subsets of T cells.•Systemic
activation of mast cells is associated with vascular pathologies during viral
infections.•Targeting of mast cell specific products has a promising therapeutic potential in
treating virus induced immune pathologies.Mast cells (MCs) are long-lived immune cells …
immune sentinels for variety of pathogens including viruses.•Mast cells initiate cellular
immune responses at the infection site by recruitment of various subsets of T cells.•Systemic
activation of mast cells is associated with vascular pathologies during viral
infections.•Targeting of mast cell specific products has a promising therapeutic potential in
treating virus induced immune pathologies.Mast cells (MCs) are long-lived immune cells …
Highlights
- At the host-environment interfaces such as skin or mucosae mast cells act as immune sentinels for variety of pathogens including viruses.
- Mast cells initiate cellular immune responses at the infection site by recruitment of various subsets of T cells.
- Systemic activation of mast cells is associated with vascular pathologies during viral infections.
- Targeting of mast cell specific products has a promising therapeutic potential in treating virus induced immune pathologies.
Mast cells (MCs) are long-lived immune cells. They are armed with preformed mediators within granules that can be instantaneously released in response to an invading pathogen, including certain viruses. At the skin and mucosae, they initiate innate immune responses and promote the development of adaptive immune responses, through cellular recruitment or antigen presentation. However, systemic MC activation may promote immune pathologies through their vasoactive proteases and biogenic amines. Recently, MC products were identified to contribute to pathologies associated with viral hemorrhagic fever, such vascular leakage and thrombocytopenia. Similar associations of MCs with disease severity have been noted for certain respiratory viral pathogens. Here we discuss the specific MC responses to viruses and their influences on functional immune outcomes during infection.
Elsevier
