Although hypoactive sexual desire disorder (HSDD) is a common condition and has long
been hypothesized to result from malfunctions of the cerebral control mechanisms that
adjust the level of sexual motivation, very little is known about the pathophysiology of this
disorder. The primary objective was to identify in patients with HSDD brain regions where
functional perturbations disrupt the regulation of sexual motivation. We used positron
emission tomography to compare seven male patients with HSDD with eight healthy men on …