Importance Heart failure with reduced ejection fraction is a progressive clinical syndrome,
and many patients' condition worsen over time despite treatment. Patients with more severe
disease are often intolerant of available medical therapies. Objective To evaluate the
efficacy and safety of omecamtiv mecarbil for the treatment of patients with severe heart
failure (HF) enrolled in the Global Approach to Lowering Adverse Cardiac Outcomes
Through Improving Contractility in Heart Failure (GALACTIC-HF) randomized clinical trial …