[HTML][HTML] A randomized placebo-controlled clinical trial of nicotinamide riboside in obese men: safety, insulin-sensitivity, and lipid-mobilizing effects
OL Dollerup, B Christensen, M Svart… - The American journal of …, 2018 - Elsevier
Background Animal studies suggest a positive role for nicotinamide riboside (NR) on insulin
sensitivity and hepatic steatosis in models of obesity and type 2 diabetes. NR, an NAD+
precursor, is a member of the vitamin B-3 family now available as an over-the-counter
supplement. Although data from preclinical trials appear consistent, potential effects and
safety need to be evaluated in human clinical trials. Objective The aim of this study was to
test the safety of dietary NR supplementation over a 12-wk period and potential to improve …
sensitivity and hepatic steatosis in models of obesity and type 2 diabetes. NR, an NAD+
precursor, is a member of the vitamin B-3 family now available as an over-the-counter
supplement. Although data from preclinical trials appear consistent, potential effects and
safety need to be evaluated in human clinical trials. Objective The aim of this study was to
test the safety of dietary NR supplementation over a 12-wk period and potential to improve …
