COVID-19 spike-host cell receptor GRP78 binding site prediction
Objectives Understanding the novel coronavirus (COVID-19) mode of host cell recognition
may help to fight the disease and save lives. The spike protein of coronaviruses is the main
driving force for host cell recognition. Methods In this study, the COVID-19 spike binding site
to the cell-surface receptor (Glucose Regulated Protein 78 (GRP78)) is predicted using
combined molecular modeling docking and structural bioinformatics. The COVID-19 spike
protein is modeled using its counterpart, the SARS spike. Results Sequence and structural …
may help to fight the disease and save lives. The spike protein of coronaviruses is the main
driving force for host cell recognition. Methods In this study, the COVID-19 spike binding site
to the cell-surface receptor (Glucose Regulated Protein 78 (GRP78)) is predicted using
combined molecular modeling docking and structural bioinformatics. The COVID-19 spike
protein is modeled using its counterpart, the SARS spike. Results Sequence and structural …
