Protective effect of antioxidants on DNA damage in leukocytes from X-linked adrenoleukodystrophy patients
DP Marchetti, B Donida, HT da Rosa, PR Manini… - International Journal of …, 2015 - Elsevier
Toxic metabolites accumulation and oxidative stress have been associated to the
pathophysiology of X-linked adrenoleukodystrophy (X-ALD), an inborn error of peroxisome
metabolism. Parameters of oxidative damage to proteins and lipids in X-ALD patients were
already described in literature; however, DNA injuries were not studied yet. Considering
that, the aims were to investigate DNA damage by comet assay in heterozygotes and
symptomatic X-ALD patients, to look for associations between DNA damage and lipid …
pathophysiology of X-linked adrenoleukodystrophy (X-ALD), an inborn error of peroxisome
metabolism. Parameters of oxidative damage to proteins and lipids in X-ALD patients were
already described in literature; however, DNA injuries were not studied yet. Considering
that, the aims were to investigate DNA damage by comet assay in heterozygotes and
symptomatic X-ALD patients, to look for associations between DNA damage and lipid …