Pathophysiology of AKI to CKD progression
Y Sato, M Takahashi, M Yanagita - Seminars in nephrology, 2020 - Elsevier
Acute kidney injury (AKI), defined as a rapid decrease in glomerular filtration rate, is a
common and devastating pathologic condition. AKI is associated with significant morbidity
and subsequent chronic kidney disease (CKD) development. Regardless of the initial insult,
CKD progression after AKI involves multiple types of cells, including proximal tubular cells,
fibroblasts, and immune cells. Although the mechanisms underlying this AKI to CKD
progression have been investigated extensively over the past decade, therapeutic strategies …
common and devastating pathologic condition. AKI is associated with significant morbidity
and subsequent chronic kidney disease (CKD) development. Regardless of the initial insult,
CKD progression after AKI involves multiple types of cells, including proximal tubular cells,
fibroblasts, and immune cells. Although the mechanisms underlying this AKI to CKD
progression have been investigated extensively over the past decade, therapeutic strategies …
