Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: progressive requirement for multiple therapies (UKPDS 49)
RC Turner, CA Cull, V Frighi, RR Holman… - Jama, 1999 - jamanetwork.com
ContextTreatment with diet alone, insulin, sulfonylurea, or metformin is known to improve
glycemia in patients with type 2 diabetes mellitus, but which treatment most frequently
attains target fasting plasma glucose (FPG) concentration of less than 7.8 mmol/L (140
mg/dL) or glycosylated hemoglobin A1c (HbA1c) below 7% is unknown. ObjectiveTo assess
how often each therapy can achieve the glycemic control target levels set by the American
Diabetes Association. DesignRandomized controlled trial conducted between 1977 and …
glycemia in patients with type 2 diabetes mellitus, but which treatment most frequently
attains target fasting plasma glucose (FPG) concentration of less than 7.8 mmol/L (140
mg/dL) or glycosylated hemoglobin A1c (HbA1c) below 7% is unknown. ObjectiveTo assess
how often each therapy can achieve the glycemic control target levels set by the American
Diabetes Association. DesignRandomized controlled trial conducted between 1977 and …
