Artificial intelligence models reveal sex-specific gene expression in aortic valve calcification
P Sarajlic, O Plunde, A Franco-Cereceda… - Basic to Translational …, 2021 - jacc.org
P Sarajlic, O Plunde, A Franco-Cereceda, M Bäck
Basic to Translational Science, 2021•jacc.orgMale and female aortic stenosis patients have distinct valvular phenotypes, increasing the
complexities in the evaluation of valvular pathophysiology. In this study, we present cutting-
edge artificial intelligence analyses of transcriptome-wide array data from stenotic aortic
valves to highlight differences in gene expression patterns between the sexes, using both
sex-differentiated transcripts and unbiased gene selections. This approach enabled the
development of efficient models with high predictive ability and determining the most …
complexities in the evaluation of valvular pathophysiology. In this study, we present cutting-
edge artificial intelligence analyses of transcriptome-wide array data from stenotic aortic
valves to highlight differences in gene expression patterns between the sexes, using both
sex-differentiated transcripts and unbiased gene selections. This approach enabled the
development of efficient models with high predictive ability and determining the most …
Summary
Male and female aortic stenosis patients have distinct valvular phenotypes, increasing the complexities in the evaluation of valvular pathophysiology. In this study, we present cutting-edge artificial intelligence analyses of transcriptome-wide array data from stenotic aortic valves to highlight differences in gene expression patterns between the sexes, using both sex-differentiated transcripts and unbiased gene selections. This approach enabled the development of efficient models with high predictive ability and determining the most significant sex-dependent contributors to calcification. In addition, analyses of function-related gene groups revealed enriched fibrotic pathways among female patients. Ultimately, we demonstrate that artificial intelligence models can be used to accurately predict aortic valve calcification by carefully analyzing sex-specific gene transcripts.
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