Engineered T cells towards TNFRSF13C (BAFFR): a novel strategy to efficiently target B‐cell acute lymphoblastic leukaemia.
N Turazzi, G Fazio, V Rossi, A Rolink… - British journal of …, 2018 - search.ebscohost.com
British journal of haematology, 2018•search.ebscohost.com
The article looks at a report regarding strategy to efficiently target B-cell acute lymphoblastic
leukaemia and receptor for B-cell activating factor. It mentions over-expressed in a wide
range of B-cell neoplasms including B-cell acute lymphoblastic leukaemia (B-ALL) but is
undetectable on B-cell precursors. It also mentions TNFSF13B also detected within the
leukaemic niche promoting tumoursurvival, proliferation and chemoresistance.
leukaemia and receptor for B-cell activating factor. It mentions over-expressed in a wide
range of B-cell neoplasms including B-cell acute lymphoblastic leukaemia (B-ALL) but is
undetectable on B-cell precursors. It also mentions TNFSF13B also detected within the
leukaemic niche promoting tumoursurvival, proliferation and chemoresistance.
Abstract
The article looks at a report regarding strategy to efficiently target B-cell acute lymphoblastic leukaemia and receptor for B-cell activating factor. It mentions over-expressed in a wide range of B-cell neoplasms including B-cell acute lymphoblastic leukaemia (B-ALL) but is undetectable on B-cell precursors. It also mentions TNFSF13B also detected within the leukaemic niche promoting tumoursurvival, proliferation and chemoresistance.
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