Exebacase Demonstrates In Vitro Synergy with a Broad Range of Antibiotics against both Methicillin-Resistant and Methicillin-Susceptible Staphylococcus aureus
A Watson, K Sauve, C Cassino… - Antimicrobial Agents and …, 2020 - Am Soc Microbiol
In vitro synergy between an antimicrobial protein lysin (cell wall hydrolase) called
exebacase and each of 12 different antibiotics was examined against Staphylococcus
aureus isolates using a nonstandard medium approved for exebacase susceptibility testing
by the Clinical and Laboratory Standards Institute. In the checkerboard assay format,
fractional inhibitory concentration index values of≤ 0.5, consistent with synergy, were
observed for the majority of interactions tested. Synergy was further confirmed in time-kill …
exebacase and each of 12 different antibiotics was examined against Staphylococcus
aureus isolates using a nonstandard medium approved for exebacase susceptibility testing
by the Clinical and Laboratory Standards Institute. In the checkerboard assay format,
fractional inhibitory concentration index values of≤ 0.5, consistent with synergy, were
observed for the majority of interactions tested. Synergy was further confirmed in time-kill …
Abstract
In vitro synergy between an antimicrobial protein lysin (cell wall hydrolase) called exebacase and each of 12 different antibiotics was examined against Staphylococcus aureus isolates using a nonstandard medium approved for exebacase susceptibility testing by the Clinical and Laboratory Standards Institute. In the checkerboard assay format, fractional inhibitory concentration index values of ≤0.5, consistent with synergy, were observed for the majority of interactions tested. Synergy was further confirmed in time-kill assays.
American Society for Microbiology