[HTML][HTML] The role of properdin in the assembly of the alternative pathway C3 convertases of complement
DE Hourcade - Journal of Biological Chemistry, 2006 - ASBMB
Complement is a powerful host defense system that contributes to both innate and acquired
immunity. There are three pathways of complement activation, the classical pathway, lectin
pathway, and alternative pathway. Each generates a C3 convertase, a serine protease that
cleaves the central complement protein, C3. Nearly all the biological consequences of
complement are dependent on the resulting cleavage products. Properdin is a positive
regulator of complement activation that stabilizes the alternative pathway convertases …
immunity. There are three pathways of complement activation, the classical pathway, lectin
pathway, and alternative pathway. Each generates a C3 convertase, a serine protease that
cleaves the central complement protein, C3. Nearly all the biological consequences of
complement are dependent on the resulting cleavage products. Properdin is a positive
regulator of complement activation that stabilizes the alternative pathway convertases …