[HTML][HTML] Mechano-or acid stimulation, two interactive modes of activation of the TREK-1 potassium channel
F Maingret, AJ Patel, F Lesage, M Lazdunski… - Journal of Biological …, 1999 - ASBMB
TREK-1 is a member of the novel structural class of K+ channels with four transmembrane
segments and two pore domains in tandem (1, 2). TREK-1 is opened by membrane stretch
and arachidonic acid. It is also an important target for volatile anesthetics (2, 3). Here we
show that internal acidification opens TREK-1. Indeed, lowering pH i shifts the pressure-
activation relationship toward positive values and leads to channel opening at atmospheric
pressure. The pH i-sensitive region in the carboxyl terminus of TREK-1 is the same that is …
segments and two pore domains in tandem (1, 2). TREK-1 is opened by membrane stretch
and arachidonic acid. It is also an important target for volatile anesthetics (2, 3). Here we
show that internal acidification opens TREK-1. Indeed, lowering pH i shifts the pressure-
activation relationship toward positive values and leads to channel opening at atmospheric
pressure. The pH i-sensitive region in the carboxyl terminus of TREK-1 is the same that is …
