Retinoids, sex steroids and glucocorticoids regulate ectocervical cell envelope formation but not the level of the envelope precursor, involucrin
GI Gorodeski, RL Eckert, WH Utian, EA Rorke - Differentiation, 1989 - Elsevier
In spite of extensive studyof the reproductive tract, little knowledge is available regarding the
function of ectocervical epithelial (ECE) cells. In the presernt study we utilized a feeder layer
of 3T3 cells to grow homogeneous cultures of human ectocervical epithelial cells and
demonstrated the presence of the cornified envelope preceursor, involucrin. Treatment of
these cultures with 1 n M Ro 136298, a synthetic analogue of tras-retinoci cid, suppresses
envelope formation 6-fold with half-maximal suppression at 0.005-0.01 nM. Treatment with 1 …
function of ectocervical epithelial (ECE) cells. In the presernt study we utilized a feeder layer
of 3T3 cells to grow homogeneous cultures of human ectocervical epithelial cells and
demonstrated the presence of the cornified envelope preceursor, involucrin. Treatment of
these cultures with 1 n M Ro 136298, a synthetic analogue of tras-retinoci cid, suppresses
envelope formation 6-fold with half-maximal suppression at 0.005-0.01 nM. Treatment with 1 …