Allergens and the airway epithelium response: gateway to allergic sensitization
BN Lambrecht, H Hammad - Journal of allergy and clinical immunology, 2014 - Elsevier
Allergic sensitization to inhaled antigens is common but poorly understood. Although lung
epithelial cells were initially merely regarded as a passive barrier impeding allergen
penetrance, we now realize that they recognize allergens through expression of pattern
recognition receptors and mount an innate immune response driven by activation of nuclear
factor κB. On allergen recognition, epithelial cells release cytokines, such as IL-1, IL-25, IL-
33, thymic stromal lymphopoietin, and GM-CSF, and endogenous danger signals, such as …
epithelial cells were initially merely regarded as a passive barrier impeding allergen
penetrance, we now realize that they recognize allergens through expression of pattern
recognition receptors and mount an innate immune response driven by activation of nuclear
factor κB. On allergen recognition, epithelial cells release cytokines, such as IL-1, IL-25, IL-
33, thymic stromal lymphopoietin, and GM-CSF, and endogenous danger signals, such as …