The bronchiolar epithelium as a prominent source of pro-inflammatory cytokines after lung irradiation
CE Rübe, D Uthe, F Wilfert, D Ludwig, K Yang… - International Journal of …, 2005 - Elsevier
Purpose: To study in detail the temporal and spatial release of the pro-inflammatory
cytokines tumor necrosis factor α, interleukin (IL)-1α, and IL-6 in the lung tissue of C57BL/6
mice after thoracic irradiation with 12 Gy. Methods and Materials: C57BL/6J mice were
exposed to either sham irradiation or a single fraction of 12 Gy delivered to the thorax.
Treated and sham-irradiated control mice were killed at 0.5 h, 1 h, 3 h, 6 h, 12 h, 24 h, 48 h,
72 h, 1 week, 2 weeks, 4 weeks, 8 weeks, 16 weeks, and 24 weeks post-irradiation (pi). Real …
cytokines tumor necrosis factor α, interleukin (IL)-1α, and IL-6 in the lung tissue of C57BL/6
mice after thoracic irradiation with 12 Gy. Methods and Materials: C57BL/6J mice were
exposed to either sham irradiation or a single fraction of 12 Gy delivered to the thorax.
Treated and sham-irradiated control mice were killed at 0.5 h, 1 h, 3 h, 6 h, 12 h, 24 h, 48 h,
72 h, 1 week, 2 weeks, 4 weeks, 8 weeks, 16 weeks, and 24 weeks post-irradiation (pi). Real …