Adoptive cellular immunotherapy for viral diseases
Viral infections remain a major cause of morbidity and mortality after pediatric hematopoietic
stem cell transplantation. Adoptive transfer of donor-derived virus-specific T cells can
reconstitute antiviral immunity in recipients and be effective both in preventing and treating
cytomegalovirus, Epstein–Barr virus and adenovirus infection. Current efforts are focused on
providing protection toward a broader range of viruses safely, rapidly and effectively.
stem cell transplantation. Adoptive transfer of donor-derived virus-specific T cells can
reconstitute antiviral immunity in recipients and be effective both in preventing and treating
cytomegalovirus, Epstein–Barr virus and adenovirus infection. Current efforts are focused on
providing protection toward a broader range of viruses safely, rapidly and effectively.
Abstract
Viral infections remain a major cause of morbidity and mortality after pediatric hematopoietic stem cell transplantation. Adoptive transfer of donor-derived virus-specific T cells can reconstitute antiviral immunity in recipients and be effective both in preventing and treating cytomegalovirus, Epstein–Barr virus and adenovirus infection. Current efforts are focused on providing protection toward a broader range of viruses safely, rapidly and effectively.
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