[HTML][HTML] T cell‐mediated rejection of kidney transplants: a personal viewpoint
PF Halloran - American Journal of Transplantation, 2010 - Elsevier
In kidney allografts, T cell mediated rejection (TCMR) is characterized by infiltration of the
interstitium by T cells and macrophages, intense IFNG and TGFB effects, and epithelial
deterioration. Recent experimental and clinical studies provide the basis for a provisional
model for TCMR. The model proposes that the major unit of cognate recognition in TCMR is
effector T cells engaging donor antigen on macrophages. This event creates the
inflammatory compartment that recruits effector and effector memory CD4 and CD8 T cells …
interstitium by T cells and macrophages, intense IFNG and TGFB effects, and epithelial
deterioration. Recent experimental and clinical studies provide the basis for a provisional
model for TCMR. The model proposes that the major unit of cognate recognition in TCMR is
effector T cells engaging donor antigen on macrophages. This event creates the
inflammatory compartment that recruits effector and effector memory CD4 and CD8 T cells …