[HTML][HTML] Mechanisms of donor-specific tolerance in recipients of haploidentical combined bone marrow/kidney transplantation
G Andreola, M Chittenden, J Shaffer, AB Cosimi… - American journal of …, 2011 - Elsevier
We recently reported long-term organ allograft survival without ongoing immunosuppression
in four of five patients receiving combined kidney and bone marrow transplantation from
haploidentical donors following nonmyeloablative conditioning. In vitro assays up to 18
months revealed donor-specific unresponsiveness. We now demonstrate that T cell recovery
is gradual and is characterized by memory-type cell predominance and an increased
proportion of CD4+ CD25+ CD127− FOXP3+ Treg during the lymphopenic period. Complete …
in four of five patients receiving combined kidney and bone marrow transplantation from
haploidentical donors following nonmyeloablative conditioning. In vitro assays up to 18
months revealed donor-specific unresponsiveness. We now demonstrate that T cell recovery
is gradual and is characterized by memory-type cell predominance and an increased
proportion of CD4+ CD25+ CD127− FOXP3+ Treg during the lymphopenic period. Complete …