[HTML][HTML] Disrupted bile acid homeostasis reveals an unexpected interaction among nuclear hormone receptors, transporters, and cytochrome P450
Sister of P-glycoprotein (SPGP) is the major hepatic bile salt export pump (BSEP).
BSEP/SPGP expression varies dramatically among human livers. The potency and
hierarchy of bile acids as ligands for the farnesyl/bile acid receptor (FXR/BAR) paralleled
their ability to induce BSEP in human hepatocyte cultures. FXR: RXR heterodimers bound to
IR1 elements and enhanced bile acid transcriptional activation of the mouse and human
BSEP/SPGP promoters. In FXR/BAR nullizygous mice, which have dramatically reduced …
BSEP/SPGP expression varies dramatically among human livers. The potency and
hierarchy of bile acids as ligands for the farnesyl/bile acid receptor (FXR/BAR) paralleled
their ability to induce BSEP in human hepatocyte cultures. FXR: RXR heterodimers bound to
IR1 elements and enhanced bile acid transcriptional activation of the mouse and human
BSEP/SPGP promoters. In FXR/BAR nullizygous mice, which have dramatically reduced …