RNF43 is frequently mutated in colorectal and endometrial cancers
M Giannakis, E Hodis, X Jasmine Mu, M Yamauchi… - Nature …, 2014 - nature.com
Nature genetics, 2014•nature.com
We report somatic mutations of RNF43 in over 18% of colorectal adenocarcinomas and
endometrial carcinomas. RNF43 encodes an E3 ubiquitin ligase that negatively regulates
Wnt signaling. Truncating mutations of RNF43 are more prevalent in microsatellite-unstable
tumors and show mutual exclusivity with inactivating APC mutations in colorectal
adenocarcinomas. These results indicate that RNF43 is one of the most commonly mutated
genes in colorectal and endometrial cancers.
endometrial carcinomas. RNF43 encodes an E3 ubiquitin ligase that negatively regulates
Wnt signaling. Truncating mutations of RNF43 are more prevalent in microsatellite-unstable
tumors and show mutual exclusivity with inactivating APC mutations in colorectal
adenocarcinomas. These results indicate that RNF43 is one of the most commonly mutated
genes in colorectal and endometrial cancers.
Abstract
We report somatic mutations of RNF43 in over 18% of colorectal adenocarcinomas and endometrial carcinomas. RNF43 encodes an E3 ubiquitin ligase that negatively regulates Wnt signaling. Truncating mutations of RNF43 are more prevalent in microsatellite-unstable tumors and show mutual exclusivity with inactivating APC mutations in colorectal adenocarcinomas. These results indicate that RNF43 is one of the most commonly mutated genes in colorectal and endometrial cancers.
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