[HTML][HTML] Interleukin-18 enhances a Th2 biased response and susceptibility to Leishmania mexicana in BALB/c mice
KJ Bryson, XQ Wei, J Alexander - Microbes and infection, 2008 - Elsevier
Interleukin-18 deficient mice on a BALB/c background display increased resistance to
cutaneous infection with Leishmania mexicana, with reduced lesion progression and
reduced parasite burdens compared with wild-type mice. Infected IL-18−/− mice had lower
antigen specific IgG1 levels and total IgE levels and conversely higher antigen specific
IgG2a levels than similarly infected wild-type mice. Splenocytes isolated from infected IL-
18−/− mice produced significantly lower levels of antigen induced IL-4 and higher levels of …
cutaneous infection with Leishmania mexicana, with reduced lesion progression and
reduced parasite burdens compared with wild-type mice. Infected IL-18−/− mice had lower
antigen specific IgG1 levels and total IgE levels and conversely higher antigen specific
IgG2a levels than similarly infected wild-type mice. Splenocytes isolated from infected IL-
18−/− mice produced significantly lower levels of antigen induced IL-4 and higher levels of …
