Susceptibility of inbred mice to Leishmania tropica infection: correlation of susceptibility with in vitro defective macrophage microbicidal activities
CA Nacy, AH Fortier, MG Pappas, RR Henry - Cellular immunology, 1983 - Elsevier
Eleven mouse strains were inoculated in footpads with amastigotes of Leishmania tropica
and observed for 12 weeks. Liver and spleen impression smears from infected mice were
examined for the presence of intracellular parasites. Four strains (BALB/cJ, C57L/J, NZW/N,
and P/J failed to heal the subcutaneous lesion and showed evidence of systemic infection;
the remaining seven strains (A/J, C3H/HeJ, C3H/HeN, C3HeB/FeJ, C57BL/6J, C57BL/10J,
and C57BL/10ScN) were each resistant to infection and resolved their lesions by Week 10 …
and observed for 12 weeks. Liver and spleen impression smears from infected mice were
examined for the presence of intracellular parasites. Four strains (BALB/cJ, C57L/J, NZW/N,
and P/J failed to heal the subcutaneous lesion and showed evidence of systemic infection;
the remaining seven strains (A/J, C3H/HeJ, C3H/HeN, C3HeB/FeJ, C57BL/6J, C57BL/10J,
and C57BL/10ScN) were each resistant to infection and resolved their lesions by Week 10 …
