Functional heterogeneity of CD4+ T cells in leishmaniasis
FY Liew - Immunology Today, 1989 - Elsevier
In this article FY Liew summarizes the evidence for the functional heterogeneity of CD4+ T
cells from studies of immune regulation in the parasitic disease, leishmaniasis. Recent
findings suggest that the heterogeneity of CD4+ T. cells may extend beyond the current Th 1
and Th 2 classification and that these T-cell subsets manifest some of their functions via the
lymphokines they secrete, and that the balance of these determines the outcome of the
infection.
cells from studies of immune regulation in the parasitic disease, leishmaniasis. Recent
findings suggest that the heterogeneity of CD4+ T. cells may extend beyond the current Th 1
and Th 2 classification and that these T-cell subsets manifest some of their functions via the
lymphokines they secrete, and that the balance of these determines the outcome of the
infection.
