[HTML][HTML] c-Src is required for oxidative stress-mediated activation of big mitogen-activated protein kinase 1 (BMK1)
J Abe, M Takahashi, M Ishida, JD Lee… - Journal of Biological …, 1997 - ASBMB
Big mitogen-activated kinase 1 (BMK1) or extracellular signal-regulated kinase-5 (ERK5)
has recently been identified as a new member of the mitogen-activated protein kinase
family. We have shown that BMK1 is activated to a greater extent by H 2 O 2 than growth
factors, suggesting that in comparison with other mitogen-activated protein kinase family
members, BMK1 is a redox-sensitive kinase. Previous investigations indicate that the
tyrosine kinase c-Src mediates signal transduction by reactive oxygen species, including H 2 …
has recently been identified as a new member of the mitogen-activated protein kinase
family. We have shown that BMK1 is activated to a greater extent by H 2 O 2 than growth
factors, suggesting that in comparison with other mitogen-activated protein kinase family
members, BMK1 is a redox-sensitive kinase. Previous investigations indicate that the
tyrosine kinase c-Src mediates signal transduction by reactive oxygen species, including H 2 …