[HTML][HTML] The fatty acid translocase gene CD36 and lingual lipase influence oral sensitivity to fat in obese subjects
The precise orosensory inputs engaged for dietary lipids detection in humans are unknown.
We evaluated whether a common single nucleotide polymorphism (rs1761667) in the CD36
gene that reduces CD36 expression and the addition of orlistat, a lipase inhibitor, to reduce
FA release from triacylglycerols (TGs), the main component of dietary fats, would attenuate
fat orosensory sensitivity in humans. Twenty-one obese subjects with different rs1761667
genotypes (6 AA, 7 AG, and 8 GG) were studied on two occasions in which oleic acid and …
We evaluated whether a common single nucleotide polymorphism (rs1761667) in the CD36
gene that reduces CD36 expression and the addition of orlistat, a lipase inhibitor, to reduce
FA release from triacylglycerols (TGs), the main component of dietary fats, would attenuate
fat orosensory sensitivity in humans. Twenty-one obese subjects with different rs1761667
genotypes (6 AA, 7 AG, and 8 GG) were studied on two occasions in which oleic acid and …