[HTML][HTML] Sequential autophosphorylation steps in the interleukin-1 receptor-associated kinase-1 regulate its availability as an adapter in interleukin-1 signaling
C Kollewe, AC Mackensen, D Neumann, J Knop… - Journal of Biological …, 2004 - ASBMB
The interleukin-1 receptor-associated kinase 1 (IRAK-1) is an important adapter in the
signaling complex of the Toll/interleukin-1 (IL-1) receptor family. Formation of the signaling
IL-1 receptor complex results in the activation and hyperphosphorylation of IRAK-1, which
leads to a pronounced shift of its apparent molecular mass in gel electrophoresis. Presently,
the individual residues phosphorylated in IRAK-1 and the consequences for IRAK-1 function
are unknown. We define sequential phosphorylation steps in IRAK-1, which are, in vitro …
signaling complex of the Toll/interleukin-1 (IL-1) receptor family. Formation of the signaling
IL-1 receptor complex results in the activation and hyperphosphorylation of IRAK-1, which
leads to a pronounced shift of its apparent molecular mass in gel electrophoresis. Presently,
the individual residues phosphorylated in IRAK-1 and the consequences for IRAK-1 function
are unknown. We define sequential phosphorylation steps in IRAK-1, which are, in vitro …
