[HTML][HTML] SMAD2 Is Essential for TGFβ-mediated Th17 Cell Generation*[S]
N Malhotra, E Robertson, J Kang - Journal of biological chemistry, 2010 - ASBMB
TGFβ is the quintessential cytokine of T cell homeostasis. TGFβ signaling is required for the
efficient differentiation and maintenance of CD4+ FOXP3+ T cells that inhibit immune
responses. Conversely, in conjunction with the inflammatory cytokine IL-6, TGFβ promotes
Th17 cell differentiation. The mechanism by which TGFβ signals synergize with IL-6 to
generate inflammatory versus immunosuppressive T cell subsets is unclear. TGFβ signaling
activates receptor SMADs, SMAD2 and SMAD3, which associate with a variety of nuclear …
efficient differentiation and maintenance of CD4+ FOXP3+ T cells that inhibit immune
responses. Conversely, in conjunction with the inflammatory cytokine IL-6, TGFβ promotes
Th17 cell differentiation. The mechanism by which TGFβ signals synergize with IL-6 to
generate inflammatory versus immunosuppressive T cell subsets is unclear. TGFβ signaling
activates receptor SMADs, SMAD2 and SMAD3, which associate with a variety of nuclear …
