[HTML][HTML] The use of antibody to complement protein C5 for salvage treatment of severe antibody-mediated rejection
JE Locke, CM Magro, AL Singer, DL Segev… - American Journal of …, 2009 - Elsevier
Desensitized patients are at high risk of developing acute antibody-mediated rejection
(AMR). In most cases, the rejection episodes are mild and respond to a short course of
plasmapheresis (PP)/low-dose IVIg treatment. However, a subset of patients experience
severe AMR associated with sudden onset oliguria. We previously described the utility of
emergent splenectomy in rescuing allografts in patients with this type of severe AMR.
However, not all patients are good candidates for splenectomy. Here we present a single …
(AMR). In most cases, the rejection episodes are mild and respond to a short course of
plasmapheresis (PP)/low-dose IVIg treatment. However, a subset of patients experience
severe AMR associated with sudden onset oliguria. We previously described the utility of
emergent splenectomy in rescuing allografts in patients with this type of severe AMR.
However, not all patients are good candidates for splenectomy. Here we present a single …
