[HTML][HTML] Functional modulation of human monocytes derived DCs by anaphylatoxins C3a and C5a
K Li, H Fazekasova, N Wang, Q Peng, SH Sacks… - Immunobiology, 2012 - Elsevier
Anaphylatoxins C3a and C5a are important modulators for dendritic cell activation and
function in mice. In order to verify the significance of these observations in man, we have
investigated the functional modulation of human monocytes derived DCs by C3a and C5a.
Here we report that engagement of C3aR or C5aR on human monocytes derived DCs
(moDCs) enhances the cell activation and their capacity for allostimulation. In addition, we
show that intracellular production of cAMP is reduced and PI3K/AKT, ERK and NF-κB …
function in mice. In order to verify the significance of these observations in man, we have
investigated the functional modulation of human monocytes derived DCs by C3a and C5a.
Here we report that engagement of C3aR or C5aR on human monocytes derived DCs
(moDCs) enhances the cell activation and their capacity for allostimulation. In addition, we
show that intracellular production of cAMP is reduced and PI3K/AKT, ERK and NF-κB …
