[HTML][HTML] Decay accelerating factor is essential for successful corneal engraftment
A Esposito, B Suedekum, J Liu, F An, J Lass… - American Journal of …, 2010 - Elsevier
In contrast to immune restrictions that pertain for solid organ transplants, the tolerogenic
milieu of the eye permits successful corneal transplantation without systemic
immunosuppression, even across a fully MHC disparate barrier. Here we show that recipient
and donor expression of decay accelerating factor (DAF or CD55), a cell surface C3/C5
convertase regulator recently shown to modulate T‐cell responses, is essential to sustain
successful corneal engraftment. Whereas wild‐type (WT) corneas transplanted into multiple …
milieu of the eye permits successful corneal transplantation without systemic
immunosuppression, even across a fully MHC disparate barrier. Here we show that recipient
and donor expression of decay accelerating factor (DAF or CD55), a cell surface C3/C5
convertase regulator recently shown to modulate T‐cell responses, is essential to sustain
successful corneal engraftment. Whereas wild‐type (WT) corneas transplanted into multiple …
