[HTML][HTML] Complement mediated renal inflammation induced by donor brain death: role of renal C5a-C5aR interaction
MB van Werkhoven, J Damman, MCRF van Dijk… - American Journal of …, 2013 - Elsevier
Kidneys retrieved from brain-dead donors have impaired allograft function after
transplantation compared to kidneys from living donors. Donor brain death (BD) triggers
inflammatory responses, including both systemic and local complement activation. The
mechanism by which systemic activated complement contributes to allograft injury remains
to be elucidated. The aim of this study was to investigate systemic C5a release after BD in
human donors and direct effects of C5a on human renal tissue. C5a levels were measured …
transplantation compared to kidneys from living donors. Donor brain death (BD) triggers
inflammatory responses, including both systemic and local complement activation. The
mechanism by which systemic activated complement contributes to allograft injury remains
to be elucidated. The aim of this study was to investigate systemic C5a release after BD in
human donors and direct effects of C5a on human renal tissue. C5a levels were measured …
