Long-term clinical and immunological effects of allergen immunotherapy
Current opinion in allergy and clinical immunology, 2011•journals.lww.com
Allergen immunotherapy induces clinical and immunological tolerance as defined by
persistence of clinical benefit and associated long-term immunological parameters after
discontinuation of treatment. These findings are largely confined to studies of subcutaneous
and sublingual immunotherapy for seasonal pollinosis. Further studies are needed to
address potential long-term clinical effects for other seasonal and perennial inhaled
allergens in both children and adults, and to identify potential biomarkers of tolerance.
persistence of clinical benefit and associated long-term immunological parameters after
discontinuation of treatment. These findings are largely confined to studies of subcutaneous
and sublingual immunotherapy for seasonal pollinosis. Further studies are needed to
address potential long-term clinical effects for other seasonal and perennial inhaled
allergens in both children and adults, and to identify potential biomarkers of tolerance.
Summary
Allergen immunotherapy induces clinical and immunological tolerance as defined by persistence of clinical benefit and associated long-term immunological parameters after discontinuation of treatment. These findings are largely confined to studies of subcutaneous and sublingual immunotherapy for seasonal pollinosis. Further studies are needed to address potential long-term clinical effects for other seasonal and perennial inhaled allergens in both children and adults, and to identify potential biomarkers of tolerance.
Lippincott Williams & Wilkins