Oleate-enriched diet improves insulin sensitivity and restores muscle protein synthesis in old rats
N Tardif, J Salles, JF Landrier, I Mothe-Satney… - Clinical nutrition, 2011 - Elsevier
BACKGROUND & AIMS: Age-related inflammation and insulin resistance (IR) have been
implicated in the inability of old muscles to properly respond to anabolic stimuli such as
amino acids (AA) or insulin. Since fatty acids can modulate inflammation and IR in muscle
cells, we investigated the effect of palmitate-enriched diet and oleate-enriched diet on
inflammation, IR and muscle protein synthesis (MPS) rate in old rats. METHODS: Twenty-
four 25-month-old rats were fed either a control diet (OC), an oleate-enriched diet (HFO) or a …
implicated in the inability of old muscles to properly respond to anabolic stimuli such as
amino acids (AA) or insulin. Since fatty acids can modulate inflammation and IR in muscle
cells, we investigated the effect of palmitate-enriched diet and oleate-enriched diet on
inflammation, IR and muscle protein synthesis (MPS) rate in old rats. METHODS: Twenty-
four 25-month-old rats were fed either a control diet (OC), an oleate-enriched diet (HFO) or a …
