[HTML][HTML] The tetraspanin CD151 functions as a negative regulator in the adhesion-dependent activation of Ras
S Sawada, M Yoshimoto, E Odintsova… - Journal of Biological …, 2003 - ASBMB
Transmembrane proteins of the tetraspanin superfamily are associated with integrins and
are thought to regulate adhesion-dependent signaling. The molecular mechanisms of this
regulation remain unknown. We used rat fibroblasts to analyze the contribution of the
tetraspanin CD151 in the adhesion-dependent signaling. Expression of CD151 specifically
attenuated adhesion-dependent activation of Ras. Furthermore, activation of PKB/c-Akt and
ERK1/2, downstream targets in the Ras signaling pathway, was also diminished in cells …
are thought to regulate adhesion-dependent signaling. The molecular mechanisms of this
regulation remain unknown. We used rat fibroblasts to analyze the contribution of the
tetraspanin CD151 in the adhesion-dependent signaling. Expression of CD151 specifically
attenuated adhesion-dependent activation of Ras. Furthermore, activation of PKB/c-Akt and
ERK1/2, downstream targets in the Ras signaling pathway, was also diminished in cells …