[HTML][HTML] Mitogenic signaling of insulin-like growth factor I in MCF-7 human breast cancer cells requires phosphatidylinositol 3-kinase and is independent of mitogen …
B Dufourny, J Alblas, HAAM van Teeffelen… - Journal of Biological …, 1997 - ASBMB
Addition of insulin-like growth factor I (IGF-I) to quiescent breast tumor-derived MCF-7 cells
causes stimulation of cyclin D1 synthesis, hyperphosphorylation of the retinoblastoma
protein pRb, DNA synthesis, and cell division. All of these effects are independent of the
mitogen-activated protein kinase (MAPK) pathway since none of them is blocked by
PD098059, the specific inhibitor of the MAPK activating kinase MEK1. This observation is
consistent with the finding that the phorbol ester 12-O-tetradecanoylphorbol-13-acetate …
causes stimulation of cyclin D1 synthesis, hyperphosphorylation of the retinoblastoma
protein pRb, DNA synthesis, and cell division. All of these effects are independent of the
mitogen-activated protein kinase (MAPK) pathway since none of them is blocked by
PD098059, the specific inhibitor of the MAPK activating kinase MEK1. This observation is
consistent with the finding that the phorbol ester 12-O-tetradecanoylphorbol-13-acetate …