[HTML][HTML] The potentiation of estrogen on insulin-like growth factor I action in MCF-7 human breast cancer cells includes cell cycle components
J Dupont, M Karas, D LeRoith - Journal of Biological Chemistry, 2000 - ASBMB
To gain insight into the mechanisms involved in the cross-talk between IGF-1 receptor (IGF-
1R) and estrogen receptor signaling pathways, we used MCF-7-derived cells (SX13), which
exhibit a 50% reduction in IGF-1R expression. Growth of NEO cells (control MCF-7 cells)
was stimulated by both IGF-1 and estradiol (E2), and the addition of both mitogens resulted
in a synergistic response. Estrogen enhanced IGF-1R signaling in NEO cells, but this effect
was markedly diminished in SX13 cells. Estrogen was also able to potentiate the IGF-1 effect …
1R) and estrogen receptor signaling pathways, we used MCF-7-derived cells (SX13), which
exhibit a 50% reduction in IGF-1R expression. Growth of NEO cells (control MCF-7 cells)
was stimulated by both IGF-1 and estradiol (E2), and the addition of both mitogens resulted
in a synergistic response. Estrogen enhanced IGF-1R signaling in NEO cells, but this effect
was markedly diminished in SX13 cells. Estrogen was also able to potentiate the IGF-1 effect …