[HTML][HTML] Ethidium bromide-induced inhibition of mitochondrial gene transcription suppresses glucose-stimulated insulin release in the mouse pancreatic β-cell line …
T Hayakawa, M Noda, K Yasuda, H Yorifuji… - Journal of Biological …, 1998 - ASBMB
Recently, a mitochondrial mutation was found to be associated with maternally inherited
diabetes mellitus (Kadowaki, T., Kadowaki, H., Mori, Y., Tobe, K., Sakuta, R., Suzuki, Y.,
Tanabe, Y, Sakura, H., Awata, T., Goto, Y., Hayakawa, T., Matsuoka, K., Kawamori, R.,
Kamada, T., Horai, S., Nonaka, I., Hagura, R., Akanuma, Y., and Yazaki, Y.(1994) N. Engl. J.
Med. 330, 962–968). In order to elucidate its etiology, we have investigated the involvement
of mitochondrial function in insulin secretion. Culture of the pancreatic β-cell line, βHC9, with …
diabetes mellitus (Kadowaki, T., Kadowaki, H., Mori, Y., Tobe, K., Sakuta, R., Suzuki, Y.,
Tanabe, Y, Sakura, H., Awata, T., Goto, Y., Hayakawa, T., Matsuoka, K., Kawamori, R.,
Kamada, T., Horai, S., Nonaka, I., Hagura, R., Akanuma, Y., and Yazaki, Y.(1994) N. Engl. J.
Med. 330, 962–968). In order to elucidate its etiology, we have investigated the involvement
of mitochondrial function in insulin secretion. Culture of the pancreatic β-cell line, βHC9, with …