Effects of long-term caloric restriction on glucose homeostasis and on the first steps of the insulin signaling system in skeletal muscle of normal and Ames dwarf …
DP Argentino, FP Dominici, MC Muñoz… - Experimental …, 2005 - Elsevier
Ames dwarf mice are a model of retarded aging and extended longevity and display
enhanced insulin sensitivity. Caloric restriction (CR) and the dwarf mutation have additive
effects on lifespan. To begin to understand the mechanisms behind this effect, an analysis of
the in vivo status of the insulin signaling system was performed in skeletal muscle from
Ames dwarf (df/df) and normal mice fed ad libitum or subjected to long-term (over 1 year)
CR. The response to CR was different in both groups of animals. In normal animals, CR …
enhanced insulin sensitivity. Caloric restriction (CR) and the dwarf mutation have additive
effects on lifespan. To begin to understand the mechanisms behind this effect, an analysis of
the in vivo status of the insulin signaling system was performed in skeletal muscle from
Ames dwarf (df/df) and normal mice fed ad libitum or subjected to long-term (over 1 year)
CR. The response to CR was different in both groups of animals. In normal animals, CR …
