[HTML][HTML] β2 subunit propeptides influence cooperative proteasome assembly
M De, K Jayarapu, L Elenich, JJ Monaco… - Journal of Biological …, 2003 - ASBMB
Vertebrate proteasomes are structurally heterogeneous, consisting of both" constitutive"(or"
standard") proteasomes and" immunoproteasomes." Constitutive proteasomes contain three
ubiquitously expressed catalytic subunits, Delta (β1), Z (β2), and X (β5), whereas
immunoproteasomes contain three interferon-γ-inducible catalytic subunits, LMP2 (β1i),
MECL (β2i), and LMP7 (β5i). We recently have demonstrated that proteasome assembly is
biased to promote immunoproteasome homogeneity when both types of catalytic subunits …
standard") proteasomes and" immunoproteasomes." Constitutive proteasomes contain three
ubiquitously expressed catalytic subunits, Delta (β1), Z (β2), and X (β5), whereas
immunoproteasomes contain three interferon-γ-inducible catalytic subunits, LMP2 (β1i),
MECL (β2i), and LMP7 (β5i). We recently have demonstrated that proteasome assembly is
biased to promote immunoproteasome homogeneity when both types of catalytic subunits …
