Adiponectin activates AMP-activated protein kinase in muscle cells via APPL1/LKB1-dependent and phospholipase C/Ca2+/Ca2+/calmodulin-dependent protein …
The binding of the adaptor protein APPL1 to adiponectin receptors is necessary for
adiponectin-induced AMP-activated protein kinase (AMPK) activation in muscle, yet the
underlying molecular mechanism remains unknown. Here we show that in muscle cells
adiponectin and metformin induce AMPK activation by promoting APPL1-dependent LKB1
cytosolic translocation. APPL1 mediates adiponectin signaling by directly interacting with
adiponectin receptors and enhances LKB1 cytosolic localization by anchoring this kinase in …
adiponectin-induced AMP-activated protein kinase (AMPK) activation in muscle, yet the
underlying molecular mechanism remains unknown. Here we show that in muscle cells
adiponectin and metformin induce AMPK activation by promoting APPL1-dependent LKB1
cytosolic translocation. APPL1 mediates adiponectin signaling by directly interacting with
adiponectin receptors and enhances LKB1 cytosolic localization by anchoring this kinase in …
