Mediation of renal cyst formation by hepatocyte growth factor
S Horie, M Kano, K Kawabe, Y Mikami, A Okubo… - The Lancet, 1994 - Elsevier
S Horie, M Kano, K Kawabe, Y Mikami, A Okubo, K Nutahara, E Higashihara
The Lancet, 1994•ElsevierHepatocyte growth factor (HGF) is a potent mitogen for renal tubular cells, and HGF and its
receptor (c-met proto-oncogene product, Met) can induce lumen formation in epithelial cells.
We measured the concentration of HGF in cyst fluids from patients with renal cystic diseases.
The concentration of HGF was high in proximal cyst fluid (mean 2· 45 vs 0· 42 ng/mL in distal
cysts). Cyclic AMP concentration was higher in distal than in proximal cysts (663 vs 6· 0
pmol/L). mRNA of HGF and Met were co-expressed in cyst walls from cases with polycystic …
receptor (c-met proto-oncogene product, Met) can induce lumen formation in epithelial cells.
We measured the concentration of HGF in cyst fluids from patients with renal cystic diseases.
The concentration of HGF was high in proximal cyst fluid (mean 2· 45 vs 0· 42 ng/mL in distal
cysts). Cyclic AMP concentration was higher in distal than in proximal cysts (663 vs 6· 0
pmol/L). mRNA of HGF and Met were co-expressed in cyst walls from cases with polycystic …
Abstract
Hepatocyte growth factor (HGF) is a potent mitogen for renal tubular cells, and HGF and its receptor (c-met proto-oncogene product, Met) can induce lumen formation in epithelial cells. We measured the concentration of HGF in cyst fluids from patients with renal cystic diseases. The concentration of HGF was high in proximal cyst fluid (mean 2·45 vs 0·42 ng/mL in distal cysts). Cyclic AMP concentration was higher in distal than in proximal cysts (663 vs 6·0 pmol/L). mRNA of HGF and Met were co-expressed in cyst walls from cases with polycystic kidney disease. These findings suggest that HGF is a growth factor that may mediate human renal cyst genesis.
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