Coordinated activation of the nuclear ubiquitin ligase Cul3-SPOP by the generation of phosphatidylinositol 5-phosphate
MW Bunce, IV Boronenkov, RA Anderson - Journal of biological chemistry, 2008 - ASBMB
Phosphoinositide signaling pathways regulate numerous processes in eukaryotic cells,
including migration, proliferation, and survival. The regulatory lipid phosphatidylinositol 4, 5-
bisphosphate is synthesized by two distinct classes of phosphatidylinositol phosphate
kinases (PIPKs), the type I and II PIPKs. Although numerous physiological functions have
been identified for type I PIPKs, little is known about the functions and regulation of type II
PIPK. Using a yeast two-hybrid screen, we identified an interaction between the type IIβ …
including migration, proliferation, and survival. The regulatory lipid phosphatidylinositol 4, 5-
bisphosphate is synthesized by two distinct classes of phosphatidylinositol phosphate
kinases (PIPKs), the type I and II PIPKs. Although numerous physiological functions have
been identified for type I PIPKs, little is known about the functions and regulation of type II
PIPK. Using a yeast two-hybrid screen, we identified an interaction between the type IIβ …
