Despite extensive research on many of the genes responsible for inherited retinal
degenerations leading to blindness, no effective treatment is currently available for patients
affected with these diseases. Among the therapeutic approaches tested on animal models of
human retinal degeneration, gene therapy using different types of viral vectors as delivery
agents has yielded promising results. We report here our results on a non-invasive, non-viral
delivery approach using transscleral iontophoresis for transfer of plasmid DNA into mouse …