Retinol dehydrogenase (RDH12) protects photoreceptors from light-induced degeneration in mice
A Maeda, T Maeda, Y Imanishi, W Sun… - Journal of biological …, 2006 - ASBMB
RDH12 has been suggested to be one of the retinol dehydrogenases (RDH) involved in the
vitamin A recycling system (visual cycle) in the eye. Loss of function mutations in the RDH12
gene were recently reported to be associated with autosomal recessive childhood-onset
severe retinal dystrophy. Here we show that RDH12 localizes to the photoreceptor inner
segments and that deletion of this gene in mice slows the kinetics of all-trans-retinal
reduction, delaying dark adaptation. However, accelerated 11-cis-retinal production and …
vitamin A recycling system (visual cycle) in the eye. Loss of function mutations in the RDH12
gene were recently reported to be associated with autosomal recessive childhood-onset
severe retinal dystrophy. Here we show that RDH12 localizes to the photoreceptor inner
segments and that deletion of this gene in mice slows the kinetics of all-trans-retinal
reduction, delaying dark adaptation. However, accelerated 11-cis-retinal production and …
