[HTML][HTML] Fibroblast growth factor 2 induction of the osteocalcin gene requires MAPK activity and phosphorylation of the osteoblast transcription factor, Cbfa1/Runx2
G Xiao, D Jiang, R Gopalakrishnan… - Journal of Biological …, 2002 - ASBMB
Fibroblast growth factor 2 (FGF-2) is an important regulator of bone formation and osteoblast
activity. However, its mechanism of action on bone cells is largely unknown. A major route
for FGF signaling is through the mitogen-activated protein kinase (MAPK) pathway. We
showed recently that this pathway is important for activation and phosphorylation of
Cbfa1/Runx2, an osteoblast-related transcription factor (Xiao, G., Jiang, D., Thomas, P.,
Benson, MD, Guan, K., Karsenty, G., and Franceschi, RT (2000) J. Biol. Chem. 275, 4453 …
activity. However, its mechanism of action on bone cells is largely unknown. A major route
for FGF signaling is through the mitogen-activated protein kinase (MAPK) pathway. We
showed recently that this pathway is important for activation and phosphorylation of
Cbfa1/Runx2, an osteoblast-related transcription factor (Xiao, G., Jiang, D., Thomas, P.,
Benson, MD, Guan, K., Karsenty, G., and Franceschi, RT (2000) J. Biol. Chem. 275, 4453 …