Characterisation of the growth and differentiation in vivo and in vitro-of bloodstream-form Trypanosoma brucei strain TREU 927
FJ van Deursen, SK Shahi, CMR Turner… - Molecular and …, 2001 - Elsevier
Trypanosoma brucei TREU 927/4 has been chosen as the reference strain targeted for
complete sequencing of the genome of the African trypanosome. This line is pleomorphic in
mammalian hosts and is fly transmissible; however it is relatively unstable with respect to
variable surface glycoprotein (VSG) expression. Therefore, we subjected TREU 927/4 to 27
rapid syringe passages through mice, and derived a cloned line which expressed Glasgow
University Trypanozoon antigen type (GUTat) 10.1 with relative stability. This line also …
complete sequencing of the genome of the African trypanosome. This line is pleomorphic in
mammalian hosts and is fly transmissible; however it is relatively unstable with respect to
variable surface glycoprotein (VSG) expression. Therefore, we subjected TREU 927/4 to 27
rapid syringe passages through mice, and derived a cloned line which expressed Glasgow
University Trypanozoon antigen type (GUTat) 10.1 with relative stability. This line also …
