During human African trypanosomiasis, trypanosomes (Trypanosoma brucei gambiense or
T. b. rhodesiense) invade the central nervous system (CNS). Mechanisms of blood-brain
barrier and blood-cerebrospinal fluid barrier leakage remain unknown. To better understand
the relationships between trypanosomes and endothelial cells, the principal cell population
of those barriers, we cultured a human bone marrow endothelial cell (HBMEC) line in the
presence or absence of T. b. gambiense, to study cell activation. As indicated by NF-κB …