Membrane-bound phospholipase C activity in normal and psoriatic epidermis.
M Bergers, PC Van de Kerkhof… - Acta dermato …, 1990 - medicaljournalssweden.se
M Bergers, PC Van de Kerkhof, R Happle, PD Mier
Acta dermato-venereologica, 1990•medicaljournalssweden.seWe report the quantification of a membrane-bound phospholipase C in human epidermis
which is active against the physiologically relevant substrate, phosphatidylinositol 4, 5-
bisphosphate. The level of this enzyme is significantly increased in the psoriatic lesion, both
on a weight and protein basis. Etiological implications of this observation are discussed.
which is active against the physiologically relevant substrate, phosphatidylinositol 4, 5-
bisphosphate. The level of this enzyme is significantly increased in the psoriatic lesion, both
on a weight and protein basis. Etiological implications of this observation are discussed.
Abstract
We report the quantification of a membrane-bound phospholipase C in human epidermis which is active against the physiologically relevant substrate, phosphatidylinositol 4, 5-bisphosphate. The level of this enzyme is significantly increased in the psoriatic lesion, both on a weight and protein basis. Etiological implications of this observation are discussed.
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